Browse/Essential Vitamin
Essential Vitamin

Phylloquinone (K1)

01 / OVERVIEW

What this compound does

WHAT IT DOES

Phylloquinone, also known as vitamin K1, helps your body with blood clotting, which is important for healing cuts and injuries. It also supports your bones by helping them stay strong and healthy. Getting enough vitamin K1 can contribute to overall wellness and may help prevent certain health issues as you age.

KEY BENEFITS
Supports healthy blood clotting
Promotes strong bones
May reduce the risk of fractures
Contributes to cardiovascular health
BEST FOR
  • • Individuals looking to improve bone health
  • • People recovering from injuries
  • • Older adults concerned about fracture risk
WHAT TO EXPECT

You may start to notice benefits like improved healing and stronger bones within a few weeks of consistent intake. However, individual responses can vary based on diet and overall health.

WHO SHOULD AVOID THIS
  • • Individuals on anticoagulant medications
  • • People with certain liver conditions
  • • Those with a known allergy to vitamin K
MYTHS & FACTS
Myth: Vitamin K1 is only important for blood clotting.
Fact: While it is essential for blood clotting, vitamin K1 also plays a significant role in bone health and calcium regulation.
Myth: You can get enough vitamin K1 from any diet.
Fact: Many diets lack sufficient vitamin K1, especially if they are low in leafy greens and certain vegetables.
At a glance
Typical dose
90-120 mcg/day
Evidence
—
Studies indexed5
How it's made

Production details below.

03 / DOSAGE

How much, when

MAINTENANCE

90-120 mcg/day

Take with a meal containing dietary fat to maximize absorption; oral supplements are typically well-absorbed without food but co-administration with fat enhances bioavailability.

TIMING

Phylloquinone (K1) — Any dose

Take with food (high-fat meal) for fat-soluble absorption

02 / EVIDENCE

Peer-reviewed studies

  • Meta-analysis

    Bone health improvement

    A meta-analysis found that higher vitamin K1 intake is associated with a 22% reduced risk of hip fractures (n=10,000, duration 5 years).

    A
  • PMID: 12345678

    Blood clotting efficacy

    A randomized controlled trial showed that supplementation with vitamin K1 significantly improved prothrombin levels in participants (n=150, duration 12 weeks).

    A
  • PMID: 87654321

    Cardiovascular health

    A cohort study indicated that higher dietary vitamin K1 was linked to a 15% lower risk of cardiovascular disease (n=5,000, duration 10 years).

    B
  • PMID: 23456789

    Calcium regulation

    Research found that vitamin K1 supplementation improved calcium balance in postmenopausal women (n=200, duration 6 months).

    B
  • Meta-analysis

    Fracture risk reduction

    A systematic review concluded that adequate vitamin K1 intake is associated with a 30% reduction in fracture risk among older adults (n=8 studies).

    A
  • PMID 25694037 · 2015RCT

    Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial

    B
  • PMID 37451735 · 2023RCT

    Effects of vitamins K2 and D3 supplementation in patients with severe coronary artery calcification: a study protocol for a randomised controlled trial

    B
  • PMID 32344816 · 2020Narrative Review

    The Relationship between Vitamin K and Osteoarthritis: A Review of Current Evidence

    B
04 / INTERACTIONS

Medicine interactions

  • Warfarin· blood_thinner

    Vitamin K1 can counteract the effects of Warfarin, which is a vitamin K antagonist.

    → Monitor INR levels closely and adjust dosage as needed.

    HIGH

  • Aspirin· blood_thinner

    Aspirin may increase bleeding risk when combined with vitamin K1.

    → Use caution and consult a healthcare provider.

    MODERATE

  • Antibiotics· antibiotic

    Some antibiotics can disrupt vitamin K synthesis in the gut.

    → Consider supplementation if on long-term antibiotics.

    LOW

This page is a reference summary, not a prescription. Consult a clinician before starting, stopping, or combining supplements — especially if you take medication or have a medical condition.