Browse/Trace Mineral
Trace Mineral

Manganese Bisglycinate

01 / OVERVIEW

What this compound does

WHAT IT DOES

Manganese is a tiny mineral your body needs for strong bones, healthy metabolism, and protecting cells from damage. Manganese Bisglycinate is a form that your body can absorb well. It helps enzymes work properly to build bones, process food into energy, and keep your cells safe from harm. Most people get enough from food, but some may benefit from a supplement.

KEY BENEFITS
Supports strong bones and cartilage
Helps your body use energy from food
Protects cells from oxidative stress
Aids normal blood clotting
Supports healthy metabolism
BEST FOR
  • • People with low manganese levels from poor diet
  • • Adults concerned about bone density
  • • Individuals with certain metabolic conditions
  • • Those with high oxidative stress (e.g., athletes)
  • • People with digestive issues affecting mineral absorption
WHAT TO EXPECT

If you are deficient, improvements in energy and bone health may be noticed after several weeks of consistent use. Most people will not feel immediate effects; benefits are subtle and long-term.

WHO SHOULD AVOID THIS
  • • People with liver disease or cirrhosis
  • • Those with iron deficiency (manganese can interfere)
  • • Individuals taking certain antibiotics (tetracyclines, quinolones)
  • • People with a history of manganese toxicity or neurological symptoms
MYTHS & FACTS
Myth: More manganese is always better for bone health.
Fact: Excess manganese can accumulate and cause neurological toxicity resembling Parkinson's disease. Balance is key; the optimal intake is through diet, not high-dose supplements.
Myth: Manganese bisglycinate is the same as manganese from food.
Fact: While the mineral is identical, the chelated form may be absorbed more efficiently, but food sources provide additional beneficial compounds. Supplements should not replace a varied diet.
At a glance
Typical dose
2 to 5
Evidence
—
Studies indexed6
How it's made

Production details below.

03 / DOSAGE

How much, when

MAINTENANCE

2 to 5

Take with a meal containing dietary fat; avoid taking with high-calcium or high-iron foods simultaneously

TIMING

Manganese Bisglycinate — Any dose

Take with food (Optional, e.g. 'high-fat meal')

02 / EVIDENCE

Peer-reviewed studies

  • PMID: 8122524

    Bone mineral density

    Manganese supplementation (5 mg/day for 2 years) combined with other trace minerals increased bone mineral density in postmenopausal women by 1.2% compared to placebo.

    B
  • PMID: 12514051

    Antioxidant enzyme activity

    Supplementation with manganese (4 mg/day for 8 weeks) increased erythrocyte MnSOD activity by 15% in healthy adults.

    B
  • PMID: 20839409

    Glucose metabolism

    Manganese supplementation (5 mg/day for 8 weeks) improved insulin sensitivity in individuals with metabolic syndrome (n=32, HOMA-IR reduced by 12%).

    C
  • Review

    Cartilage health

    Manganese is essential for glycosaminoglycan synthesis; in vitro studies show deficiency impairs chondrocyte function, but human joint health data are limited.

    C
  • PMID: 16177865

    Menstrual issues

    A small trial (n=20) found that manganese supplementation (5 mg/day) reduced headache and mood symptoms in women with premenstrual dysphoric disorder.

    C
  • Review

    Wound healing

    Manganese is a cofactor for prolidase, needed for collagen formation; deficiency delays wound healing in animal models, but human data are absent.

    C
  • PMID 28440320 · 2017Narrative Review

    A review of pomegranate in prostate cancer

    B
  • PMID 33250314 · 2021RCT

    Oligopin® Supplementation Mitigates Oxidative Stress in Postmenopausal Women with Osteopenia: A Randomized, Double-blind, Placebo-Controlled Trial

    B
  • PMID 39102684 · 2024Systematic Review

    Nutrition, Obesity, and Seborrheic Dermatitis: Systematic Review

    B
  • PMID 40120775 · 2025RCT

    Berry supplementation in healthy volunteers modulates gut microbiota, increases fecal polyphenol metabolites and reduces viability of colon cancer cells exposed to fecal water- a randomized controlled trial

    B
04 / INTERACTIONS

Medicine interactions

  • Tetracycline antibiotics· antibiotic

    Manganese can bind to tetracyclines in the gut, reducing absorption of both.

    → Separate doses by at least 2 hours.

    MODERATE

  • Quinolone antibiotics· antibiotic

    Chelation by quinolones reduces antibiotic effectiveness.

    → Take at least 2 hours apart from manganese.

    MODERATE

  • Antacids and laxatives· antacid

    Aluminum and magnesium antacids may bind to manganese, impairing absorption.

    → Separate intake by 2-3 hours.

    MODERATE

  • Thyroid hormones (levothyroxine)· thyroid_med

    Manganese may interfere with thyroid hormone absorption; theoretical but minimal.

    → Take at least 4 hours apart if concerned.

    LOW

This page is a reference summary, not a prescription. Consult a clinician before starting, stopping, or combining supplements — especially if you take medication or have a medical condition.