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Peptide

Sermorelin

01 / OVERVIEW

What this compound does

WHAT IT DOES

Sermorelin is an older, well-characterised peptide that prompts your pituitary to make its own growth hormone. It was once an approved medicine.

KEY BENEFITS
Stimulates natural GH release
Long track record as a diagnostic agent
Shorter-acting, more physiologic pulses
BEST FOR
  • • Adults exploring GH-axis support
  • • People preferring a more studied GHRH
WHAT TO EXPECT

Prescribed by some anti-aging clinics; the original branded product was discontinued in the US.

WHO SHOULD AVOID THIS
  • • People with active cancer
  • • Pregnant or breastfeeding people
MYTHS & FACTS
Myth:
Fact:
At a glance
Typical dose
200-500 mcg at bedtime (clinical protocols)
Evidence
—
Studies indexed1
How it's made

GRF(1-29) peptide synthesised, HPLC-purified, lyophilised.

03 / DOSAGE

How much, when

MAINTENANCE

200-500 mcg at bedtime (clinical protocols)

subcutaneous before sleep

TIMING

Sermorelin — Bedtime dose

Take on empty stomach

02 / EVIDENCE

Peer-reviewed studies

  • PMID: 2137137

    Stimulates endogenous GH

    Sermorelin reliably provokes pituitary GH release and was used diagnostically for GH deficiency.

    B
  • PMID 2137137 · 1990human

    Sermorelin in the diagnosis of growth hormone deficiency

    Reliable GH provocation

    B
04 / INTERACTIONS

Medicine interactions

  • Glucocorticoids· steroid

    Suppress the GH response to GHRH.

    → Expect reduced efficacy; discuss with clinician.

    MODERATE

  • Thyroid hormone· thyroid

    Can modulate GH response.

    → Monitor if titrating thyroid therapy.

    LOW

This page is a reference summary, not a prescription. Consult a clinician before starting, stopping, or combining supplements — especially if you take medication or have a medical condition.