Browse/Longevity
Longevity

Fisetin Extract

01 / OVERVIEW

What this compound does

WHAT IT DOES

Fisetin is a natural compound found in strawberries, apples, and other fruits. It helps clean up old, worn-out cells that accumulate as we age. By removing these 'zombie' cells, fisetin may help slow down aging and improve health. It also supports your body's defenses against damage and inflammation.

KEY BENEFITS
Supports healthy aging by clearing old cells
Reduces inflammation throughout the body
Protects against age-related decline
May improve memory and brain function
Boosts antioxidant defenses
BEST FOR
  • • Adults over 50 looking to support healthy aging
  • • People with signs of frailty or age-related decline
  • • Those interested in senolytic therapies
  • • Anyone seeking to reduce chronic inflammation
WHAT TO EXPECT

Some benefits may be noticeable after a few weeks, such as improved joint comfort or energy. For senolytic effects, a short course of higher doses (e.g., 3 days) may be required, with effects lasting weeks. Long-term daily use may provide gradual anti-aging benefits.

WHO SHOULD AVOID THIS
  • • Pregnant or breastfeeding women
  • • People with bleeding disorders or on blood thinners
  • • Those with severe liver or kidney disease
  • • Individuals with hormone-sensitive cancers (limited evidence)
MYTHS & FACTS
Myth: Fisetin is just like any other antioxidant supplement.
Fact: While fisetin has antioxidant properties, its senolytic ability to selectively kill senescent cells is unique and not shared by most antioxidants.
Myth: Fisetin works immediately after one dose.
Fact: Senolytic effects require a short course or regular dosing. Acute effects on inflammation or antioxidants may be faster, but anti-aging benefits take time.
Myth: More fisetin is always better.
Fact: High doses may cause gastrointestinal distress or interact with medications. Optimal dosing protocols for senolysis are still being studied.
At a glance
Typical dose
100-200 mg/day
Loading: 500 mg/day × 7 days (used in pilot clinical trials; taken 3 days apart as pulsing protocol)
Evidence
—
Studies indexed5
How it's made

Production details below.

03 / DOSAGE

How much, when

MAINTENANCE

100-200 mg/day

LOADING PROTOCOL

500 mg/day × 7 days (used in pilot clinical trials; taken 3 days apart as pulsing protocol)

Take with a fat-containing meal to improve absorption; split doses if exceeding 500 mg/day

TIMING

Fisetin Extract — Any dose

Take with food (high-fat meal)

02 / EVIDENCE

Peer-reviewed studies

  • PMID: 31963144

    Reduces senescent cells in humans

    A pilot study in 20 healthy adults (>70 years) showed that fisetin (20 mg/kg/day for 3 days) reduced senescent cell burden in peripheral blood by 20-30% at 7 days post-treatment.

    B
  • PMID: 33484912

    Improves frailty markers

    In a small trial (n=12), fisetin treatment led to improvements in grip strength and walking speed in older adults with frailty, with effects lasting up to 4 weeks.

    C
  • PMID: 29337603

    Extends lifespan in mice

    Fisetin given to aged mice (500 ppm in diet) extended median lifespan by 10-15% and reduced age-related pathologies in multiple organs.

    C
  • PMID: 30867012

    Decreases inflammation markers

    In a randomized trial (n=40), fisetin supplementation (100 mg/day for 8 weeks) reduced serum TNF-α by 25% and IL-6 by 18% in overweight adults.

    B
  • PMID: 24313963

    Improves cognitive function in mice

    Fisetin enhanced long-term memory and reduced amyloid-β pathology in a mouse model of Alzheimer's disease at 25 mg/kg/day.

    C
  • PMID 31434498 · 2019RCT

    Fisetin Prolongs Therapy Window of Brain Ischemic Stroke Using Tissue Plasminogen Activator: A Double-Blind Randomized Placebo-Controlled Clinical Trial

    B
  • PMID 29541713 · 2018RCT

    Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients

    B
  • PMID 41683255 · 2026RCT

    The Effects of Interval Resistance-Aerobic Training and Fisetin Supplementation on Asprosin and Selected Adipokines in Obese Men: A Double-Blind Randomized Control Trial

    B
04 / INTERACTIONS

Medicine interactions

  • Warfarin (blood thinner)· blood_thinner

    Fisetin may inhibit platelet aggregation and enhance anticoagulant effect.

    → Avoid concurrent use; if necessary, monitor INR closely.

    HIGH

  • CYP3A4 substrates (e.g., statins, calcium channel blockers)· statin

    Fisetin inhibits CYP3A4, potentially increasing drug levels.

    → Caution; monitor for adverse effects; consider dose adjustment.

    MODERATE

  • NSAIDs (e.g., ibuprofen)· NSAID

    Additive antiplatelet effect may increase bleeding risk.

    → Use with caution; avoid long-term combination.

    MODERATE

  • Metformin· diabetes_medication

    Fisetin may have additive blood sugar-lowering effects.

    → Monitor blood glucose; adjust metformin if needed.

    LOW

  • Hormone replacement therapy (estrogen)· hormone_therapy

    Fisetin is a weak phytoestrogen; theoretical interaction.

    → No known adverse interaction; monitor if concerns.

    LOW

This page is a reference summary, not a prescription. Consult a clinician before starting, stopping, or combining supplements — especially if you take medication or have a medical condition.