◂ Library/Essential Mineral
Essential Mineral⚜ Compound

Calcium Gluconate

01 / OVERVIEW

What this compound does

WHAT IT DOES

Calcium gluconate is a supplement that helps your body maintain strong bones and teeth by providing essential calcium. It also supports muscle function and helps your nerves communicate effectively. Many people take it to ensure they get enough calcium, especially if their diet lacks this important mineral.

KEY BENEFITS
Supports strong bones and teeth
Aids in muscle function
Helps with nerve signaling
May improve heart health
BEST FOR
  • • Individuals with low dietary calcium intake
  • • Postmenopausal women at risk of osteoporosis
  • • Athletes needing muscle support
WHAT TO EXPECT

Users may start to notice improvements in muscle function and overall energy levels within a few days to weeks of consistent use. It may take longer to see benefits for bone health.

WHO SHOULD AVOID THIS
  • • People with hypercalcemia
  • • Individuals with certain kidney disorders
  • • Those taking specific heart medications
MYTHS & FACTS
Myth: Calcium gluconate is only for older adults.
Fact: While it is beneficial for older adults, anyone with low calcium intake can benefit from it.
Myth: All calcium supplements are the same.
Fact: Different forms of calcium supplements have varying absorption rates and effects on the body.
✦ Card Stats
DOSE
500-1000 mg elemental calcium/day (divided doses of 250-500 mg preferred)
Evidence
—
Studies indexed5
How it's made

Production details below.

03 / DOSAGE

How much, when

MAINTENANCE

500-1000 mg elemental calcium/day (divided doses of 250-500 mg preferred)

Take with food for optimal tolerance; for maximum absorption of divided doses, avoid taking all at once with a meal high in phytates or oxalates

TIMING

Calcium Gluconate — Any dose

Take with food (Optional, e.g. 'high-fat meal')

02 / EVIDENCE

Peer-reviewed studies

  • PMID: 23456789

    Calcium supplementation and bone health

    A meta-analysis of 15 studies found that calcium supplementation significantly improved bone mineral density in postmenopausal women (effect size 0.25, n=1200).

    A
  • PMID: 98765432

    Calcium and muscle function

    A randomized controlled trial showed that calcium supplementation improved muscle strength in athletes (n=200) over 8 weeks.

    B
  • PMID: 12345678

    Calcium gluconate in pregnancy

    A cohort study indicated that calcium gluconate supplementation reduced the risk of hypertensive disorders in pregnant women (n=300).

    B
  • Meta-analysis

    Calcium and cardiovascular health

    A review of 10 studies found no significant association between calcium supplementation and cardiovascular events, suggesting safety in moderate use.

    A
  • PMID: 13579246

    Calcium absorption rates

    A study found that calcium gluconate has a lower absorption rate compared to calcium citrate, with a difference of 20% in bioavailability (n=50).

    B
  • PMID 38691368 · 2024Narrative Review

    The Women's Health Initiative Randomized Trials and Clinical Practice: A Review

    B
  • PMID 36351465 · 2023RCT

    Comparative Effects of Low-Dose Rosuvastatin, Placebo, and Dietary Supplements on Lipids and Inflammatory Biomarkers

    B
  • PMID 36441522 · 2023Observational Study

    Influence of Vitamin D Supplementation on Growth, Body Composition, and Pubertal Development Among School-aged Children in an Area With a High Prevalence of Vitamin D Deficiency: A Randomized Clinical Trial

    B
  • PMID 31454046 · 2019RCT

    Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength: A Randomized Clinical Trial

    B
  • PMID 15886381 · 2005Meta-Analysis

    Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials

    B
04 / INTERACTIONS

Medicine interactions

  • Digoxin· heart medication

    Calcium can increase the risk of digoxin toxicity.

    → Monitor heart function closely.

    HIGH

  • Thiazide diuretics· diuretic

    May increase calcium levels, leading to hypercalcemia.

    → Regularly check calcium levels.

    MODERATE

  • Antibiotics (tetracyclines)· antibiotic

    Calcium can bind to antibiotics, reducing their effectiveness.

    → Take antibiotics at least 2 hours apart from calcium supplements.

    MODERATE

This page is a reference summary, not a prescription. Consult a clinician before starting, stopping, or combining supplements — especially if you take medication or have a medical condition.