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Peptide

Tirzepatide

01 / OVERVIEW

What this compound does

WHAT IT DOES

Tirzepatide (Mounjaro/Zepbound) is a newer FDA-approved injection that hits two gut hormones at once, giving some of the biggest weight-loss results in trials.

KEY BENEFITS
Up to ~21% weight loss
Excellent blood-sugar control
Dual GIP + GLP-1 action
BEST FOR
  • • People with type 2 diabetes
  • • Adults with obesity meeting criteria
WHAT TO EXPECT

Weekly injection with slow dose escalation; appetite and weight fall over months. Prescription required.

WHO SHOULD AVOID THIS
  • • Personal/family history of medullary thyroid carcinoma or MEN2
  • • Pregnant people
  • • History of pancreatitis (caution)
MYTHS & FACTS
Myth:
Fact:
At a glance
Typical dose
5-15 mg subcutaneously once weekly (approved)
Loading: Titrate from 2.5 mg/week monthly
Evidence
—
Studies indexed2
How it's made

Manufactured to pharmacopeial standards as a dual-agonist acylated peptide.

03 / DOSAGE

How much, when

MAINTENANCE

5-15 mg subcutaneously once weekly (approved)

LOADING PROTOCOL

Titrate from 2.5 mg/week monthly

weekly injection, titrated

TIMING

Tirzepatide — Any dose

Standard dosing.

02 / EVIDENCE

Peer-reviewed studies

  • PMID: 35658024

    Large weight loss

    SURMOUNT-1 showed up to ~21% body-weight reduction at the highest dose vs placebo.

    A
  • PMID: 34170647

    Superior glycemic control

    SURPASS trials showed strong HbA1c reductions, often exceeding GLP-1-only agents.

    A
  • PMID 35658024 · 2022rct

    Tirzepatide once weekly for obesity (SURMOUNT-1)

    Up to ~21% weight loss

    A
04 / INTERACTIONS

Medicine interactions

  • Insulin / sulfonylureas· antidiabetic

    Additive glucose lowering, hypoglycemia risk.

    → Reduce doses; monitor glucose.

    HIGH

  • Oral contraceptives· hormonal

    Delayed gastric emptying may reduce absorption after dose escalation.

    → Consider backup contraception per labeling.

    MODERATE

This page is a reference summary, not a prescription. Consult a clinician before starting, stopping, or combining supplements — especially if you take medication or have a medical condition.