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Peptide

Semax

01 / OVERVIEW

What this compound does

WHAT IT DOES

Semax is a Russian nootropic peptide nasal spray used for focus, memory, and brain protection, including after strokes. Western evidence is thin.

KEY BENEFITS
May improve focus and cognition
Neuroprotective in stroke models
Raises brain growth factors (BDNF/NGF)
BEST FOR
  • • People researching nootropic/neuroprotective peptides
WHAT TO EXPECT

Nasal spray; not FDA-approved. Evidence mostly from Russian clinical use.

WHO SHOULD AVOID THIS
  • • Pregnant or breastfeeding people
  • • Those wanting FDA-approved cognitive treatment
MYTHS & FACTS
Myth:
Fact:
At a glance
Typical dose
300-600 mcg/day intranasal (research protocols)
Evidence
—
Studies indexed2
How it's made

Heptapeptide synthesised and HPLC-purified; nasal formulation.

03 / DOSAGE

How much, when

MAINTENANCE

300-600 mcg/day intranasal (research protocols)

intranasal, divided

TIMING

Semax — Morning dose

Standard dosing.

02 / EVIDENCE

Peer-reviewed studies

  • PMID: 9612756

    Neuroprotection (clinical, Russia)

    Used in Russian stroke protocols with reported neuroprotective and recovery benefits.

    C
  • PMID: 19240462

    BDNF upregulation

    Increases BDNF/NGF expression in animal models, supporting nootropic claims.

    C
  • PMID 9612756 · 1997human

    Semax neuroprotection in ischemic stroke

    Improved recovery

    C
04 / INTERACTIONS

Medicine interactions

  • Stimulants· stimulant

    Possible additive activating effects (theoretical).

    → Monitor for overstimulation.

    LOW

This page is a reference summary, not a prescription. Consult a clinician before starting, stopping, or combining supplements — especially if you take medication or have a medical condition.