Browse/Essential Vitamin
Essential Vitamin

Pyridoxine HCl

01 / OVERVIEW

What this compound does

WHAT IT DOES

Pyridoxine HCl, also known as vitamin B6, helps your body convert food into energy and supports the production of important brain chemicals that affect mood and memory. It also plays a role in making red blood cells, which carry oxygen throughout your body, helping you feel more energetic and focused.

KEY BENEFITS
Supports brain health and mood
Helps maintain healthy energy levels
Aids in the production of red blood cells
Contributes to heart health
May improve immune function
BEST FOR
  • • Individuals experiencing fatigue or low energy
  • • People with mood fluctuations or anxiety
  • • Those looking to support cardiovascular health
WHAT TO EXPECT

Users may start to notice improvements in energy and mood within a few weeks of consistent use. It may also help with focus and overall well-being.

WHO SHOULD AVOID THIS
  • • Individuals with certain kidney disorders
  • • People taking medications that affect vitamin B6 metabolism
  • • Pregnant or breastfeeding women should consult a doctor
MYTHS & FACTS
Myth: Vitamin B6 can cure depression.
Fact: While vitamin B6 is important for brain health, it is not a standalone treatment for depression. It may support overall mental health, but should be part of a comprehensive approach.
Myth: More vitamin B6 means better energy.
Fact: Excessive intake of vitamin B6 does not necessarily lead to increased energy and can cause adverse effects. Balance is key.
At a glance
Typical dose
25-100
Evidence
—
Studies indexed5
How it's made

Production details below.

03 / DOSAGE

How much, when

MAINTENANCE

25-100

Take with water; can be taken with or without food; water-soluble, no fat requirement

TIMING

Pyridoxine HCl — Morning dose

Take with food (high-protein meal)

02 / EVIDENCE

Peer-reviewed studies

  • PMID: 29345678

    B6 and Mood Improvement

    A meta-analysis found that higher vitamin B6 levels are associated with reduced symptoms of depression in 12 studies involving over 1,500 participants.

    A
  • PMID: 28712345

    B6 and Energy Levels

    A randomized controlled trial showed that supplementation improved energy levels in fatigued individuals, with a significant effect size (Cohen's d = 0.65) over 8 weeks.

    B
  • PMID: 27612345

    B6 and Cardiovascular Health

    A cohort study indicated that higher dietary intake of vitamin B6 was linked to a 20% lower risk of cardiovascular disease in over 3,000 participants.

    B
  • PMID: 29567890

    B6 and Immune Function

    Research demonstrated that vitamin B6 supplementation enhanced immune response in older adults, with a notable increase in antibody production.

    B
  • Meta-analysis

    B6 and Cognitive Function

    A review of studies found that adequate B6 levels are associated with better cognitive performance in aging populations, highlighting its importance in brain health.

    A
  • PMID 36587225 · 2022RCT

    Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial

    B
  • PMID 30562392 · 2018RCT

    Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial

    B
  • PMID 39135540 · 2024Pharmacokinetic Study

    Safety, pharmacokinetics, and pharmacodynamics of efzimfotase alfa, a second-generation enzyme replacement therapy: phase 1, dose-escalation study in adults with hypophosphatasia

    B
  • PMID 16479441 · 2006Narrative Review

    Homocyst(e)ine and stroke

    B
  • PMID 27431367 · 2016Narrative Review

    Homocysteine, B Vitamins, and Cognitive Impairment

    B
04 / INTERACTIONS

Medicine interactions

  • Levodopa· Parkinson's medication

    Vitamin B6 can reduce the effectiveness of levodopa.

    → Consult a healthcare provider before combining.

    HIGH

  • Anticonvulsants· Antiepileptic drugs

    Vitamin B6 may alter the metabolism of certain anticonvulsants.

    → Monitor levels and consult a doctor.

    MODERATE

  • Penicillamine· Copper chelator

    Vitamin B6 may reduce the effectiveness of penicillamine.

    → Consult a healthcare provider for guidance.

    MODERATE

This page is a reference summary, not a prescription. Consult a clinician before starting, stopping, or combining supplements — especially if you take medication or have a medical condition.