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Peptide

PT-141 (Bremelanotide)

01 / OVERVIEW

What this compound does

WHAT IT DOES

PT-141 (Vyleesi) is an FDA-approved peptide that boosts sexual desire by acting on the brain, not blood flow like Viagra.

KEY BENEFITS
Increases sexual desire centrally
FDA-approved for premenopausal HSDD
Works independent of vascular effect
BEST FOR
  • • Premenopausal women with HSDD (approved use)
  • • People researching libido peptides
WHAT TO EXPECT

Used on-demand by injection before anticipated activity; nausea is common.

WHO SHOULD AVOID THIS
  • • People with uncontrolled high blood pressure or cardiovascular disease
  • • Pregnant people
MYTHS & FACTS
Myth:
Fact:
At a glance
Typical dose
1.75 mg subcutaneously as needed (max 1/day, 8/month)
Evidence
—
Studies indexed1
How it's made

Cyclic heptapeptide synthesised to pharmacopeial standards.

03 / DOSAGE

How much, when

MAINTENANCE

1.75 mg subcutaneously as needed (max 1/day, 8/month)

on-demand before activity

TIMING

PT-141 (Bremelanotide) — Any dose

Standard dosing.

02 / EVIDENCE

Peer-reviewed studies

  • PMID: 31356516

    Improved sexual desire

    Phase 3 RECONNECT trials showed improved desire and reduced distress in premenopausal women with HSDD.

    A
  • PMID 31356516 · 2019rct

    Bremelanotide for HSDD in premenopausal women (RECONNECT)

    Improved desire

    A
04 / INTERACTIONS

Medicine interactions

  • Antihypertensives· blood_pressure

    Transient BP/HR changes with dosing.

    → Use cautiously; avoid in uncontrolled hypertension.

    MODERATE

  • Naltrexone (oral)· various

    Bremelanotide can slow gastric emptying and reduce naltrexone absorption.

    → Per labeling, avoid combined use.

    MODERATE

This page is a reference summary, not a prescription. Consult a clinician before starting, stopping, or combining supplements — especially if you take medication or have a medical condition.