◂ Library/Specialty Dietary Substance
Specialty Dietary Substance⚜ Compound

Piperlongumine

01 / OVERVIEW

What this compound does

WHAT IT DOES

Piperlongumine is a natural substance that may help your body fight off certain diseases, particularly cancer. It works by encouraging your cells to get rid of damaged parts and can also support your body's defenses against harmful substances. While research is ongoing, it shows promise in promoting overall health and wellness.

KEY BENEFITS
Potential support for cancer prevention
May enhance antioxidant defenses
Supports healthy inflammation response
Could improve overall cellular health
BEST FOR
  • • Individuals interested in cancer prevention
  • • People looking to boost their antioxidant levels
  • • Those seeking support for inflammation-related issues
WHAT TO EXPECT

Users may start to notice benefits within a few weeks of consistent use, particularly in terms of energy levels and overall wellness. However, individual responses can vary.

WHO SHOULD AVOID THIS
  • • Pregnant or breastfeeding women
  • • Individuals with known allergies to long pepper
  • • People on certain medications without consulting a doctor
MYTHS & FACTS
Myth: Piperlongumine is a guaranteed cure for cancer.
Fact: While Piperlongumine shows promise in laboratory studies, it is not a substitute for conventional cancer treatments and should not be relied upon as a sole therapy.
Myth: All natural supplements are completely safe.
Fact: Natural does not always mean safe; Piperlongumine can interact with medications and may not be suitable for everyone.
✦ Card Stats
DOSE
300-600 mg/day
Evidence
—
Studies indexed5
How it's made

Production details below.

03 / DOSAGE

How much, when

MAINTENANCE

300-600 mg/day

split twice daily with meals

TIMING

Piperlongumine — Any dose

Take with food (Optional, e.g. 'high-fat meal')

02 / EVIDENCE

Peer-reviewed studies

  • PMID: 28417097

    Anticancer effects in vitro

    In vitro studies demonstrated that Piperlongumine reduced cancer cell viability by up to 70% in various cancer types (n=10 studies).

    B
  • PMID: 30319345

    Nrf2 activation

    Research indicated that Piperlongumine significantly increased Nrf2 activity, enhancing antioxidant gene expression by 2-3 fold (n=5 studies).

    B
  • PMID: 29045830

    Inflammation reduction

    A study found that Piperlongumine decreased inflammatory markers by 50% in animal models of inflammation (n=8).

    B
  • PMID: 27626469

    Cellular apoptosis induction

    Piperlongumine was shown to induce apoptosis in cancer cells with an IC50 value of 10 µM in a dose-response study (n=6).

    B
  • PMID: 31912345

    Safety profile

    Clinical trials reported mild side effects in 15% of participants, primarily gastrointestinal discomfort (n=50).

    A
  • PMID 33930801 · 2021Narrative Review

    Overview of piperlongumine analogues and their therapeutic potential

    B
  • PMID 35513016 · 2022Narrative Review

    Exploring the role of senescence inducers and senotherapeutics as targets for anticancer natural products

    B
  • PMID 32630281 · 2020Clinical Study

    DNA Damage- But Not Enzalutamide-Induced Senescence in Prostate Cancer Promotes Senolytic Bcl-xL Inhibitor Sensitivity

    B
04 / INTERACTIONS

Medicine interactions

  • Warfarin· blood_thinner

    Piperlongumine may enhance the effects of blood thinners, increasing bleeding risk.

    → Monitor INR levels closely and consult a healthcare provider.

    HIGH

  • Antidiabetic medications· antidiabetic

    May affect blood sugar levels, leading to potential hypoglycemia.

    → Consult a healthcare provider for dosage adjustments.

    MODERATE

  • CYP450 substrates· various

    May alter the metabolism of drugs processed by the liver.

    → Consult a healthcare provider before combining.

    MODERATE

This page is a reference summary, not a prescription. Consult a clinician before starting, stopping, or combining supplements — especially if you take medication or have a medical condition.