Browse/Essential Vitamin
Essential Vitamin

Nicotinamide Riboside (NR)

01 / OVERVIEW

What this compound does

WHAT IT DOES

Nicotinamide Riboside is a supplement that helps your body produce more energy at the cellular level. By boosting a vital compound in your cells, it may support better metabolism and even help your brain function more effectively. Some studies suggest it could be beneficial for older adults looking to maintain their energy levels and overall health.

KEY BENEFITS
Supports energy production in cells
May enhance brain function
Potentially aids in metabolic health
Could help with age-related decline
BEST FOR
  • • Older adults seeking more energy
  • • Individuals interested in metabolic health
  • • People looking to support brain health
WHAT TO EXPECT

Users may start to notice increased energy levels and improved mental clarity within a few weeks of consistent use. However, individual responses can vary.

WHO SHOULD AVOID THIS
  • • Pregnant or breastfeeding women
  • • Individuals with certain metabolic disorders
  • • Those on specific medications without consulting a doctor
MYTHS & FACTS
Myth: Nicotinamide Riboside is just another form of vitamin B3.
Fact: While it is related to vitamin B3, NR has unique properties and mechanisms that differentiate it from other forms, particularly in its ability to boost NAD+ levels.
Myth: All supplements that increase NAD+ are the same.
Fact: Different NAD+ precursors have varying effects on absorption and metabolism, making some more effective than others.
At a glance
Typical dose
250-500 mg/day
Evidence
—
Studies indexed2
How it's made

Production details below.

03 / DOSAGE

How much, when

MAINTENANCE

250-500 mg/day

morning with or without food

TIMING

Nicotinamide Riboside (NR) — Morning dose

Standard dosing.

02 / EVIDENCE

Peer-reviewed studies

  • PMID: 27487330

    NAD+ elevation in humans

    Randomized trial confirmed dose-dependent NAD+ increase in blood.

    A
  • PMID: 29924215

    Cardiovascular markers

    NR supplementation reduced aortic stiffness in older adults.

    B
  • PMID 37478182 · 2023Narrative Review

    What is really known about the effects of nicotinamide riboside supplementation in humans

    B
  • PMID 35235774 · 2022RCT

    The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease

    B
  • PMID 27721479 · 2016Clinical Study

    Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

    B
  • PMID 31278280 · 2019Safety Study

    Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults

    B
  • PMID 32383227 · 2021Mechanistic Study

    Possible mechanisms of cancer prevention by nicotinamide

    B
04 / INTERACTIONS

Medicine interactions

  • Blood thinners· blood_thinner

    NR may influence blood flow and metabolism.

    → Consult a healthcare provider before combining.

    MODERATE

  • Diabetes medications· antidiabetic

    NR may affect glucose metabolism.

    → Monitor blood sugar levels closely.

    MODERATE

  • Statins· statin

    Potential for altered lipid metabolism.

    → Consult with a healthcare provider.

    LOW

This page is a reference summary, not a prescription. Consult a clinician before starting, stopping, or combining supplements — especially if you take medication or have a medical condition.