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Peptide

MOTS-c

01 / OVERVIEW

What this compound does

WHAT IT DOES

MOTS-c is a peptide made by your mitochondria that seems to improve metabolism and exercise capacity in animals. Human data is early.

KEY BENEFITS
May improve insulin sensitivity (animal data)
Studied for exercise and metabolic health
BEST FOR
  • • People researching metabolic/longevity peptides
WHAT TO EXPECT

Not FDA-approved; sold as a research chemical. Human benefits unproven.

WHO SHOULD AVOID THIS
  • • Pregnant or breastfeeding people
  • • Those wanting proven human therapies
MYTHS & FACTS
Myth:
Fact:
At a glance
Typical dose
5-10 mg/week (research protocols)
Evidence
—
Studies indexed2
How it's made

16-amino-acid peptide synthesised and HPLC-purified.

03 / DOSAGE

How much, when

MAINTENANCE

5-10 mg/week (research protocols)

subcutaneous

TIMING

MOTS-c — Morning dose

Take on empty stomach

02 / EVIDENCE

Peer-reviewed studies

  • PMID: 25738459

    Metabolic regulation (preclinical)

    MOTS-c improves insulin sensitivity and metabolic flexibility in mouse models via AMPK signalling.

    C
  • PMID: 34593699

    Exercise capacity (preclinical)

    Enhanced physical capacity and metabolic homeostasis in aged mice.

    C
  • PMID 25738459 · 2015animal

    MOTS-c regulates metabolic homeostasis and insulin sensitivity

    Improved metabolism

    C
04 / INTERACTIONS

Medicine interactions

  • Antidiabetics· antidiabetic

    Possible additive effects on insulin sensitivity (theoretical).

    → Monitor glucose if diabetic.

    LOW

This page is a reference summary, not a prescription. Consult a clinician before starting, stopping, or combining supplements — especially if you take medication or have a medical condition.