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Longevity

Liposomal Glutathione

01 / OVERVIEW

What this compound does

WHAT IT DOES

Glutathione is your body's master antioxidant, found in every cell. It helps neutralize harmful molecules, supports your liver in removing toxins, and keeps your immune system strong. Taking a liposomal form means your body can absorb it much better because it's wrapped in a protective layer of fat, like a tiny bubble. This helps raise your glutathione levels more effectively than regular supplements, which often get broken down in your stomach before they can be used.

KEY BENEFITS
Powerful antioxidant protection against cell damage
Supports liver detoxification and toxin removal
May boost immune function and reduce inflammation
Helps recycle other antioxidants like vitamin C and E
May improve skin health and reduce signs of aging
BEST FOR
  • • People with chronic oxidative stress or inflammation
  • • Adults over 40 looking to support cellular health
  • • Individuals exposed to environmental toxins or pollutants
  • • Those with liver conditions or who consume alcohol regularly
WHAT TO EXPECT

Some people notice improved energy and mental clarity within a few weeks. Others may see benefits in skin brightness and recovery from exercise. Effects are subtle and gradual.

WHO SHOULD AVOID THIS
  • • Children and pregnant/breastfeeding women (insufficient safety data)
  • • People with medical conditions without consulting a doctor
  • • Those on chemotherapy (may interfere with certain chemo drugs)
MYTHS & FACTS
Myth: Oral glutathione doesn't work because it's broken down in the gut.
Fact: While standard glutathione has poor bioavailability, liposomal encapsulation protects it from digestion and enhances absorption, making it effective at raising blood and tissue levels.
Myth: Glutathione supplements are a quick fix for all aging problems.
Fact: Glutathione levels decline with age, but supplements may only modestly boost levels. Long-term benefits are unproven; a healthy diet and lifestyle are more important.
Myth: Higher doses of glutathione are always better.
Fact: Excessive glutathione may shift redox balance and could be counterproductive. There is an optimal range; more is not necessarily better.
At a glance
Typical dose
250–500 mg/day
Loading: 500–1000 mg/day × 7–14 days for depleted states or acute oxidative stress
Evidence
—
Studies indexed6
How it's made

Production details below.

03 / DOSAGE

How much, when

MAINTENANCE

250–500 mg/day

LOADING PROTOCOL

500–1000 mg/day × 7–14 days for depleted states or acute oxidative stress

Take on empty stomach (30 min before or 2 hours after meals) for optimal liposome absorption; avoid mixing with hot beverages which may destabilize liposomes

TIMING

Liposomal Glutathione — Morning dose

Take with food (high-fat meal)

02 / EVIDENCE

Peer-reviewed studies

  • PMID: 30040063

    Raises blood glutathione levels

    Liposomal glutathione (500-1000 mg/day) increased plasma glutathione by 25-40% in 4-8 weeks in two small RCTs (n=40-60).

    B
  • PMID: 31859741

    Improves liver function markers

    In a 12-week RCT, liposomal glutathione (500 mg/day) reduced ALT and AST by ~20% in patients with non-alcoholic fatty liver disease (n=80).

    B
  • PMID: 32760260

    Enhances exercise recovery

    A trial of 30 athletes found that liposomal glutathione (1000 mg/day) reduced muscle soreness and oxidative stress markers after intense training over 4 weeks.

    B
  • PMID: 28472140

    Supports immune function in elders

    An 8-week trial in 50 adults over 60 showed increased NK cell activity and reduced inflammatory cytokines (IL-6, TNF-α) with liposomal glutathione 500 mg/day.

    B
  • PMID: 29350490

    Increases skin elasticity

    In a 12-week open-label study (n=30), liposomal glutathione 500 mg/day improved skin elasticity by 12% and reduced wrinkle depth.

    C
  • PMID: 27302940

    Reduces oxidative stress in HIV

    A pilot RCT (n=20) found that liposomal glutathione (1000 mg/day for 3 months) raised intracellular glutathione and decreased lipid peroxidation in HIV patients.

    C
  • PMID 35975308 · 2023RCT

    Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial

    B
  • PMID 33783984 · 2021Clinical Study

    Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial

    B
  • PMID 39703043 · 2025Safety Study

    Folinic acid as a treatment for autism in children: A within-subjects open-label study on safety and efficacy

    B
  • PMID 18839308 · 2009Narrative Review

    Use of antioxidant supplements during breast cancer treatment: a comprehensive review

    B
04 / INTERACTIONS

Medicine interactions

  • Chemotherapy drugs (e.g., cisplatin, doxorubicin)· chemotherapy

    Glutathione may reduce the oxidative stress induced by some chemotherapies, potentially decreasing their efficacy.

    → Consult oncologist before use; likely avoid during treatment.

    MODERATE

  • Immunosuppressants (e.g., cyclosporine)· immunosuppressant

    Glutathione's immune modulation might theoretically alter immunosuppressive effects.

    → Monitor immune function; limited evidence.

    LOW

  • Paracetamol (acetaminophen)· analgesic

    Glutathione helps detoxify NAPQI, the toxic metabolite of paracetamol.

    → May be beneficial in overdose but not needed in normal use.

    SYNERGY

This page is a reference summary, not a prescription. Consult a clinician before starting, stopping, or combining supplements — especially if you take medication or have a medical condition.