Browse/Specialty Dietary Substance
Specialty Dietary Substance

Hyaluronic Acid

01 / OVERVIEW

What this compound does

WHAT IT DOES

Hyaluronic acid is a substance that helps keep your skin and joints hydrated and healthy. It works by attracting and holding onto water, making it important for maintaining the elasticity of your skin and the lubrication of your joints. Many people take it as a supplement to support their overall joint and skin health.

KEY BENEFITS
Improved skin hydration and elasticity
Enhanced joint lubrication
Support for wound healing
Potential reduction in joint pain
May promote healthier aging
BEST FOR
  • • Individuals with dry skin
  • • Athletes looking for joint support
  • • People experiencing joint discomfort
  • • Those interested in anti-aging skin care
  • • Individuals recovering from injuries
WHAT TO EXPECT

Users may start to notice improvements in skin hydration and joint comfort within a few weeks of consistent use. Effects can vary based on individual health and dosage.

WHO SHOULD AVOID THIS
  • • People with allergies to rooster combs
  • • Individuals with certain autoimmune diseases
  • • Pregnant or breastfeeding women
  • • Those undergoing surgery
  • • Individuals on blood thinners
MYTHS & FACTS
Myth: Hyaluronic acid is only for skin care.
Fact: While it is popular in skin care, hyaluronic acid also plays a significant role in joint health and hydration.
Myth: All hyaluronic acid supplements are the same.
Fact: Quality and molecular weight can vary significantly among supplements, affecting their effectiveness.
At a glance
Typical dose
80-200 mg/day
Evidence
—
Studies indexed2
How it's made

Production details below.

03 / DOSAGE

How much, when

MAINTENANCE

80-200 mg/day

oral — with water; independent of meals

TIMING

Hyaluronic Acid — Morning dose

Standard dosing.

02 / EVIDENCE

Peer-reviewed studies

  • PMID: 22849165

    Knee joint pain

    Oral HA reduced knee pain and improved mobility in mild-moderate OA.

    B
  • PMID: 28761365

    Skin hydration

    Oral HA improved skin hydration and wrinkle appearance over 12 weeks.

    B
  • PMID 38009035 · 2023RCT

    Oral administration of hyaluronic acid to improve skin conditions via a randomized double-blind clinical test

    B
  • PMID 31715233 · 2020Narrative Review

    Hyaluronic acid: A review on its biology, aspects of drug delivery, route of administrations and a special emphasis on its approved marketed products and recent clinical studies

    B
  • PMID 26840887 · 2016RCT

    Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study

    B
  • PMID 37686801 · 2023Safety Study

    A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial to Evaluate the Efficacy and Safety of a Krill Oil, Astaxanthin, and Oral Hyaluronic Acid Complex on Joint Health in People with Mild Osteoarthritis

    B
  • PMID 39918266 · 2025Safety Study

    Investigating the Efficacy and Safety of Oral Cicaglocal on Wound Healing After Mohs Surgery in Patients With Skin Cancer: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial

    B
04 / INTERACTIONS

Medicine interactions

  • Warfarin· blood_thinner

    Hyaluronic acid may enhance the effects of blood thinners, increasing bleeding risk.

    → Monitor INR levels closely.

    MODERATE

  • Aspirin· blood_thinner

    May increase the risk of gastrointestinal bleeding when combined.

    → Use caution and consult a healthcare provider.

    MODERATE

  • Diuretics· diuretic

    May alter fluid balance in the body.

    → Consult a healthcare provider for monitoring.

    LOW

This page is a reference summary, not a prescription. Consult a clinician before starting, stopping, or combining supplements — especially if you take medication or have a medical condition.