Browse/Specialty Dietary Substance
Specialty Dietary Substance

DHEA

01 / OVERVIEW

What this compound does

WHAT IT DOES

DHEA is a hormone that your body naturally produces, especially in the adrenal glands. As you age, your levels of this hormone can drop, which might affect your energy, mood, and overall health. Some people take DHEA supplements to help boost their hormone levels and improve various aspects of their well-being.

KEY BENEFITS
May improve mood and well-being
Supports energy levels
Potentially enhances muscle strength
May aid in better sleep quality
BEST FOR
  • • Adults over 40 looking for energy support
  • • Individuals experiencing mood fluctuations
  • • People wanting to enhance physical performance
WHAT TO EXPECT

Users may start to notice effects within a few weeks, including improved mood and energy levels. However, individual responses can vary widely.

WHO SHOULD AVOID THIS
  • • Pregnant or breastfeeding women
  • • Individuals with hormone-sensitive conditions
  • • People taking hormone therapies
MYTHS & FACTS
Myth: DHEA is a miracle cure for aging.
Fact: While some studies suggest benefits, evidence is mixed, and it is not a guaranteed solution for aging-related issues.
Myth: DHEA is completely safe for everyone.
Fact: DHEA can have side effects and interactions, and it is not suitable for everyone, especially those with certain health conditions.
At a glance
Typical dose
25-50 mg/day
Evidence
—
Studies indexed2
How it's made

Production details below.

03 / DOSAGE

How much, when

MAINTENANCE

25-50 mg/day

morning with food; test hormone levels first

TIMING

DHEA — Morning dose

Take with food for fat-soluble absorption

02 / EVIDENCE

Peer-reviewed studies

  • PMID: 11602537

    Bone mineral density (women)

    DHEA supplementation improved BMD in older women with adrenal insufficiency.

    B
  • PMID: 10468053

    Libido and well-being

    DHEA improved sexual function and well-being in women with adrenal insufficiency.

    B
  • PMID 37880791 · 2023RCT

    The effects of intermittent fasting diet alone or in combination with probiotic supplementation in comparison with calorie-restricted diet on metabolic and hormonal profile in patients with polycystic ovary syndrome: study protocol for a randomized clinical trial

    B
  • PMID 33137599 · 2021RCT

    Effects of curcumin supplementation on blood glucose, insulin resistance and androgens in patients with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial

    B
  • PMID 38794708 · 2024Mechanistic Study

    Examining the Effects of Nutrient Supplementation on Metabolic Pathways via Mitochondrial Ferredoxin in Aging Ovaries

    B
  • PMID 35428430 · 2022Narrative Review

    Nutraceuticals and Phytotherapy in Men's Health: Antioxidants, Pro-oxidants, and a Novel Opportunity for Lifestyle Changes

    B
  • PMID 35573993 · 2022Systematic Review

    The Evaluation of Ovarian Function Recovery Following Treatment of Primary Ovarian Insufficiency: A Systematic Review

    B
04 / INTERACTIONS

Medicine interactions

  • Antidepressants· SSRI

    DHEA may influence serotonin levels, potentially altering antidepressant effectiveness.

    → Monitor mood closely and adjust antidepressant dosage if necessary.

    MODERATE

  • Blood thinners· blood_thinner

    DHEA may affect hormone levels that influence blood clotting.

    → Consult a healthcare provider before combining.

    MODERATE

  • Hormonal contraceptives· hormonal_contraceptive

    DHEA may alter hormone levels, potentially affecting contraceptive efficacy.

    → Use additional contraceptive methods and consult a healthcare provider.

    MODERATE

This page is a reference summary, not a prescription. Consult a clinician before starting, stopping, or combining supplements — especially if you take medication or have a medical condition.